Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture
- Authors
- Ndlovu, T. M.; Ward, A. C.; Glassey, J.; Eskildsen, J.; Akay, G.
- Issue Date
- Apr-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Polymerisation; Functionalization; Micro-porous matrix growth; Submerged growth; "Streptomyces coelicolor" A3(2); Antibiotic
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.49, pp 799 - 806
- Pages
- 8
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 49
- Start Page
- 799
- End Page
- 806
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64602
- DOI
- 10.1016/j.msec.2015.01.052
- ISSN
- 0928-4931
1873-0191
- Abstract
- A novel functionalized micro-porous matrix was developed with well-controlled physicochemical proprieties such as pore size and surface chemistry. The matrix was used as a solid support in the growth of "Streptomyces coelicolor" A3(2) to enhance the production of antibiotics. The results shown support a higher production of prodigiosin and actinorhodin with overall production increase of 2-5 and 6-17, respectively, compared to conventional submerged liquid culture, offering a potential improvement in volumetric productivity. Scanning Electron Microscopy was used to evaluate pore size as well as bacterial adhesion, penetration, proliferation and migration within the micro-porous matrix. (C) 2015 Elsevier B.V. All rights reserved.
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