Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Kyu | - |
dc.contributor.author | Eun, Jung Woo | - |
dc.contributor.author | Bae, Hyun Jin | - |
dc.contributor.author | Shen, Qingyu | - |
dc.contributor.author | Park, Se Jin | - |
dc.contributor.author | Kim, Hyung Seok | - |
dc.contributor.author | Park, Soha | - |
dc.contributor.author | Ahn, Young Min | - |
dc.contributor.author | Park, Won Sang | - |
dc.contributor.author | Lee, Jung Young | - |
dc.contributor.author | Nam, Suk Woo | - |
dc.date.accessioned | 2023-03-08T20:40:06Z | - |
dc.date.available | 2023-03-08T20:40:06Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1354-750X | - |
dc.identifier.issn | 1366-5804 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64810 | - |
dc.description.abstract | Objective: Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure. Methods: Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD25 or LD5 values, to Sprague-Dawley. Results: Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs. Conclusions: These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/1354750X.2013.847121 | - |
dc.identifier.bibliographicCitation | BIOMARKERS, v.18, no.8, pp 706 - 715 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000327504100010 | - |
dc.identifier.scopusid | 2-s2.0-84889789900 | - |
dc.citation.endPage | 715 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 706 | - |
dc.citation.title | BIOMARKERS | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Dichloromethane | - |
dc.subject.keywordAuthor | Ethylbenzene | - |
dc.subject.keywordAuthor | Molecular signature | - |
dc.subject.keywordAuthor | Trichloroethylene | - |
dc.subject.keywordAuthor | Volatile organic compound | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HYDROCARBONS | - |
dc.subject.keywordPlus | TOXICOLOGY | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.