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Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver
- Authors
- Kim, Jeong Kyu; Eun, Jung Woo; Bae, Hyun Jin; Shen, Qingyu; Park, Se Jin; Kim, Hyung Seok; Park, Soha; Ahn, Young Min; Park, Won Sang; Lee, Jung Young; Nam, Suk Woo
- Issue Date
- Dec-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Biomarker; Dichloromethane; Ethylbenzene; Molecular signature; Trichloroethylene; Volatile organic compound
- Citation
- BIOMARKERS, v.18, no.8, pp 706 - 715
- Pages
- 10
- Journal Title
- BIOMARKERS
- Volume
- 18
- Number
- 8
- Start Page
- 706
- End Page
- 715
- ISSN
- 1354-750X
1366-5804
- Abstract
- Objective: Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure. Methods: Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD25 or LD5 values, to Sprague-Dawley. Results: Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs. Conclusions: These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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