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Highly sensitive cancer marker detection on gold-patterned microarray chip using surface-enhanced Raman scattering imaging
- Authors
- Lee M.; Lee J.-H.; Lim H.-W.; Park J.-G.; Choo, Jaebum
- Issue Date
- Nov-2009
- Publisher
- Chemical and Biological Microsystems Society
- Keywords
- Hydrophobic pattern; Immunoassay; Microarray; SERS Imaging
- Citation
- Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp 466 - 468
- Pages
- 3
- Journal Title
- Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
- Start Page
- 466
- End Page
- 468
- ISSN
- 0000-0000
- Abstract
- This paper reports a novel method for the highly sensitive cancer marker detection using a gold-patterned microarray chip and a surface-enhanced Raman scattering imaging (SERSi). In this work, we designed and fabricated a conceptually new gold-patterened glass microarray chip. Here, gold patterned hydrophilic spots are completely isolated from hydrophobic surfaces, and the hydrophobic/hydrophilic hybrid property of the microarrays greatly improves the biomolecule deposition, spot uniformity, replication, and reproducibility. This gold-patterned microarray chp has been successfully used for a highly sensitive cancer marker detection. © 2009 CBMS.
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