Apoptosis and Expression of AQP5 and TGF-beta in the Irradiated Rat Submandibular Gland
DC Field | Value | Language |
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dc.contributor.author | Choi, Jin Hwa | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Lee, Seung Hee | - |
dc.contributor.author | Kwon, Eun Kyung | - |
dc.date.accessioned | 2023-03-08T23:38:31Z | - |
dc.date.available | 2023-03-08T23:38:31Z | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.issn | 2005-9256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65202 | - |
dc.description.abstract | Purpose To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-beta(TGF-beta) in the rat submandibular gland (SMG). Materials and Methods SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-beta was determined by immunohistochemical staining. Results At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-beta expression by ductal cells were evident. Conclusion Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-beta expression in different SMG cell types. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.title | Apoptosis and Expression of AQP5 and TGF-beta in the Irradiated Rat Submandibular Gland | - |
dc.type | Article | - |
dc.identifier.doi | 10.4143/crt.2009.41.3.145 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.41, no.3, pp 145 - 154 | - |
dc.identifier.kciid | ART001376503 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000208487300005 | - |
dc.citation.endPage | 154 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 145 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Submandibular gland | - |
dc.subject.keywordAuthor | Radiation | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | AQP5 | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
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