Apoptosis and Expression of AQP5 and TGF-beta in the Irradiated Rat Submandibular Gland
- Authors
- Choi, Jin Hwa; Wu, Hong-Gyun; Jung, Kyeong Cheon; Lee, Seung Hee; Kwon, Eun Kyung
- Issue Date
- Sep-2009
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Submandibular gland; Radiation; Apoptosis; AQP5; TGF-beta
- Citation
- CANCER RESEARCH AND TREATMENT, v.41, no.3, pp 145 - 154
- Pages
- 10
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 41
- Number
- 3
- Start Page
- 145
- End Page
- 154
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65202
- DOI
- 10.4143/crt.2009.41.3.145
- ISSN
- 1598-2998
2005-9256
- Abstract
- Purpose To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-beta(TGF-beta) in the rat submandibular gland (SMG). Materials and Methods SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-beta was determined by immunohistochemical staining. Results At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-beta expression by ductal cells were evident. Conclusion Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-beta expression in different SMG cell types.
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