Signal Pathway of 17 beta-Estradiol-Induced MUC5B Expression in Human Airway Epithelial Cells
- Authors
- Choi, Hye Joung; Chung, Yoo-Sam; Kim, Hyun Jik; Moon, Uk Yeol; Choi, Yeon Ho; Van Seuningen, Isabelle; Baek, Seung Joon; Yoon, Ho-Geun; Yoon, Joo-Heon
- Issue Date
- Feb-2009
- Publisher
- AMER THORACIC SOC
- Keywords
- MUC5B; estrogen; ER alpha; CREB
- Citation
- AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, v.40, no.2, pp 168 - 178
- Pages
- 11
- Journal Title
- AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Volume
- 40
- Number
- 2
- Start Page
- 168
- End Page
- 178
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65298
- DOI
- 10.1165/rcmb.2007-0377OC
- ISSN
- 1044-1549
1535-4989
- Abstract
- MUC5B is a major mucin of the human respiratory tract, and it is not clear how MUC5B expression is regulated in various airway diseases. The goal of this study was to determine the mechanisms by which 17 beta-estradiol induces MUC5B gene expression in airway epithelial cells. It was found that E2, a sex hormone, stimulates MUC5B gene overexpression by interaction with estrogen receptor alpha (ER alpha) and by acting through extracellular signal-regulated kinase 1/2 (ERK1/2)mitogen-activated protein kinase (MAPK). Pretreatment with ER antagonist ICl 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression. It was also found that the activation of p90 ribosomal S 6 protein kinase 1 (RSK1), cAMP-response element-binding protein (CREB), and cAMP-response element (CRE) (-956 region of the MUC5B promoter)-responsive signaling cascades via ERK1/2 MAPK are crucial aspects of the intracellular mechanisms that mediate MUC5B gene expression. Taken together, these studies give additional insights into the molecular mechanism of hormone-induced MUC5B gene expression and enhance our understanding of abnormal mucin secretion in response to hormonal imbalances.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65298)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.