A DNA - Gold nanoparticle-based colorimetric competition assay for the detection of cysteine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J.-S. | - |
dc.contributor.author | Ulmann, P.A. | - |
dc.contributor.author | Han, M.S. | - |
dc.contributor.author | Mirkin, C.A. | - |
dc.date.accessioned | 2023-03-09T00:20:52Z | - |
dc.date.available | 2023-03-09T00:20:52Z | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.issn | 1530-6992 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/65347 | - |
dc.description.abstract | We report the development of a highly sensitive and selective colorimetric detection method for cysteine based upon oligonucleotide-functionalized gold nanoparticle probes that contain strategically placed thymidine-thymidine (T-T) mismatches complexed with Hg 2+. This assay relies upon the distance-dependent optical properties of gold nanoparticles, the sharp melting transition of oligonucleotide-linked nanoparticle aggregates, and the very selective coordination of Hg 2+ with cysteine. The concentration of cysteine can be determined by monitoring with the naked eye or a UV-vis spectrometer the temperature at which the purple-to-red color change associated with aggregate dissociation takes place. This assay does not utilize organic cosolvents, enzymatic reactions, light-sensitive dye molecules, lengthy protocols, or sophisticated instrumentation thereby overcoming some of the limitations of more conventional methods. © 2008 American Chemical Society. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | A DNA - Gold nanoparticle-based colorimetric competition assay for the detection of cysteine | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/nl0727563 | - |
dc.identifier.bibliographicCitation | Nano Letters, v.8, no.2, pp 529 - 533 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-40449085426 | - |
dc.citation.endPage | 533 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 529 | - |
dc.citation.title | Nano Letters | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | Cysteine | - |
dc.subject.keywordPlus | Enzymatic reactions | - |
dc.subject.keywordPlus | Organic cosolvents | - |
dc.subject.keywordPlus | Bioassay | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | Gold | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.subject.keywordPlus | Oligonucleotides | - |
dc.subject.keywordPlus | Amino acids | - |
dc.subject.keywordPlus | cysteine | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | gold | - |
dc.subject.keywordPlus | nanomaterial | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | chemistry | - |
dc.subject.keywordPlus | colorimetry | - |
dc.subject.keywordPlus | conformation | - |
dc.subject.keywordPlus | crystallization | - |
dc.subject.keywordPlus | equipment | - |
dc.subject.keywordPlus | equipment design | - |
dc.subject.keywordPlus | evaluation | - |
dc.subject.keywordPlus | genetic procedures | - |
dc.subject.keywordPlus | instrumentation | - |
dc.subject.keywordPlus | macromolecule | - |
dc.subject.keywordPlus | materials testing | - |
dc.subject.keywordPlus | methodology | - |
dc.subject.keywordPlus | nanotechnology | - |
dc.subject.keywordPlus | particle size | - |
dc.subject.keywordPlus | surface property | - |
dc.subject.keywordPlus | ultrastructure | - |
dc.subject.keywordPlus | Biosensing Techniques | - |
dc.subject.keywordPlus | Colorimetry | - |
dc.subject.keywordPlus | Crystallization | - |
dc.subject.keywordPlus | Cysteine | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | Equipment Design | - |
dc.subject.keywordPlus | Equipment Failure Analysis | - |
dc.subject.keywordPlus | Gold | - |
dc.subject.keywordPlus | Macromolecular Substances | - |
dc.subject.keywordPlus | Materials Testing | - |
dc.subject.keywordPlus | Molecular Conformation | - |
dc.subject.keywordPlus | Nanostructures | - |
dc.subject.keywordPlus | Nanotechnology | - |
dc.subject.keywordPlus | Particle Size | - |
dc.subject.keywordPlus | Surface Properties | - |
dc.description.journalRegisteredClass | scopus | - |
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