Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis
- Authors
- Choi, Sun Young; Oh, Chang Taek; Kwon, Tae-Rin; Kwon, Hyun Jung; Choi, Eun Ja; Jang, Yu-Jin; Kim, Hye Sung; Chu, Hong; Mun, Seog Kyun; Kim, Myeung Nam; Kim, Beom Joon
- Issue Date
- Sep-2016
- Publisher
- SPRINGER LONDON LTD
- Keywords
- Gain-switched 311-tun Ti:Sapphire laser; Atopic dermatitis
- Citation
- LASERS IN MEDICAL SCIENCE, v.31, no.7, pp 1437 - 1445
- Pages
- 9
- Journal Title
- LASERS IN MEDICAL SCIENCE
- Volume
- 31
- Number
- 7
- Start Page
- 1437
- End Page
- 1445
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6598
- DOI
- 10.1007/s10103-016-2006-8
- ISSN
- 0268-8921
1435-604X
- Abstract
- Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD.
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