The influence of surface ligand chemistry for the synthesis of blue fluorescent gold nanoclusters for the detection of serotonin in biofluids
- Authors
- Borse, S.; Murthy, Z.V.P.; Park, Tae Jung; Kailasa, S.K.
- Issue Date
- Feb-2023
- Publisher
- Royal Society of Chemistry
- Citation
- New Journal of Chemistry, v.47, no.6, pp 3075 - 3083
- Pages
- 9
- Journal Title
- New Journal of Chemistry
- Volume
- 47
- Number
- 6
- Start Page
- 3075
- End Page
- 3083
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66314
- DOI
- 10.1039/d2nj04797g
- ISSN
- 1144-0546
1369-9261
- Abstract
- Gold nanoclusters have been widely applied for the sensing of biomolecules, biomarkers and drugs. Herein, a simple method for the fabrication of gold nanoclusters (Au NCs) is put forward by using two ligands, namely 6-thioguanine (6-TG) and tryptophan (Trp). First, blue emitting 6-TG-Au NCs have been synthesized and then the surface of the 6-TG-Au NCs was modified with Trp. This surface modification results in the enhancement of the fluorescence intensity with a red shift in the emission peak confirming the formation of 6-TG-Trp-Au NCs. The as-synthesized 6-TG-Trp-Au NCs work as a fluorescent sensor for the sensitive recognition of biomarker serotonin. The 6-TG-Trp-Au NCs exhibit a strong emission peak at 473 nm when excited at 380 nm. The 6-TG-Trp-Au NC-based method shows a fluorescence turn-off mechanism toward serotonin with a linear range of 0.041-1.25 μM and limit of detection of 5.58 nM. Moreover, 6-TG-Trp-Au NCs show a quick response for the development of a cost-effective analytical strategy for a serotonin assay in biofluids. © 2023 The Royal Society of Chemistry.
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