일부 한국인의 혈청 cerulopasmin 정상 참고치 설정 및 질환별 비교

Abstract

Ceruloplasmin has been investigated as one of the useful biologic index for early diagnosis of atherolsclerosis. However, there was no normal reference value taking into account the confounders in Korea. This study was performed to estimate the normal reference values and present the confounders of ceruloplasmin. Also we compared of serum ceruloplasmin levels among normal reference group and three abnormal groups: 475 healthy subjects, 53 liver dysfunctions, 72 positive test of chronic inflammatory diseases, and 89 hypercholesterolemias. Mean serum ceruloplasmin level of healthy subjects were 41.6±7.6㎎/㎗ in males and 42.1±7.2㎎/㎗ in females, respectively. It was tend to increase of ceruloplasmin by age in both sexes. However, the statistical difference was not found by age group between both sexes. Statistically significant correlations were found between serum ceruloplasmin and age, body mass index(BMI), white blood cell(WBC) and triglyceride(TG) in males and age, BMI, WBC and total cholestrol(TG) in females. After adjustment for age, BMI,WBC and TG in males and age, BMI, WBC and TG in females, significant elevations of serum ceruloplasmin were found in liver dysfunction(p=0.0077) and positive test of chonic inflammatory disease(p=0.0217) in males and in oisitive test of chronic inflammatory disease(p=0.0023) and hypercholestolemia(p=0.0124) in females relative to healthy reference subjects. There is no statistical difference among liver dysfunction, postive test of chronic inflammatory disease, and hypercholesterolemia.