Differential block of two types of sodium channels by anticonvulsants
- Authors
- Song, Jin-Ho; Nagata, Keiichi; Huang, Chao-Sheng; Yeh, Jay Z.; Narahashi, Toshio
- Issue Date
- Nov-1996
- Publisher
- RAPID SCIENCE PUBLISHERS
- Keywords
- action potential; carbamazepine; diphenylhydantoin; dorsal root ganglion; phenytoin; sodium channel; tetrodotoxin-resistant; tetrodotoxin-sensitive
- Citation
- NEUROREPORT, v.7, no.18, pp 3031 - 3036
- Pages
- 6
- Journal Title
- NEUROREPORT
- Volume
- 7
- Number
- 18
- Start Page
- 3031
- End Page
- 3036
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66629
- DOI
- 10.1097/00001756-199611250-00047
- ISSN
- 0959-4965
1473-558X
- Abstract
- The differential effects of the anticonvulsants phenytoin and carbamazepine on the sodium channels of rat dorsal root ganglion (DRG) neurons were studied using the patch clamp technique. The action potentials from tetrodotoxin-resistant (TTX-R) cells were less sensitive to phenytoin and carbamazepine than those from tetrodotoxin-sensitive (TTX-S) cells. The steady-state inactivation curve for TTX-S sodium channels was shifted by as much as 20.6 mV and 11.4 mV by phenytoin and carbamazepine at 300 mu M, respectively, yet the curve for TTX-R sodium channels was shifted only by 6.0 mV and 6.9 mV, respectively. Thus, the differential action potential block of TTX-S and TTX-R cells by phenytoin and carbamazepine is due to different voltage dependence of and differential drug effects on the inactivation kinetics of two types of sodium channels.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66629)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.