Inhibition of tumor growth by plant-derived mAb
DC Field | Value | Language |
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dc.contributor.author | Ko, K | - |
dc.contributor.author | Steplewski, Z | - |
dc.contributor.author | Glogowska, M | - |
dc.contributor.author | Koprowski, H | - |
dc.date.accessioned | 2023-06-08T02:40:58Z | - |
dc.date.available | 2023-06-08T02:40:58Z | - |
dc.date.issued | 2005-05 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66692 | - |
dc.description.abstract | The tumor-associated antigen EpCAM (GA733-2) is a highly expressed target on adenocarcinoma cells, as defined by murine mAb CO17-1A. We recently developed a transgenic plant system for the safe and inexpensive production of large quantities of mAb CO17-1A as a future source of clinical-grade protein. Although the glycosylation pattern of plant-derived mAb (mAb(P)) CO17-1A differs considerably from that of the mammalian-derived mAb (mAb(M)), we show here that the biological activity of both mAbs is quite similar. mAbP heavy and light chains assembled to bind the recombinant antigen GA733-2E and specifically bound to human SW948 colorectal carcinoma cells expressing the antigen GA733-2 to the same extent as mAb(M). mAb(P) was as effective as mAb(M) CO17-1A in inhibiting tumor growth of xenotransplanted SW948 cells in nude mice. These results suggest the promise of transgenic plants as a useful alternative way to produce full-size mAb for cancer immunotherapy. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Inhibition of tumor growth by plant-derived mAb | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.0502533102 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.102, no.19, pp 7026 - 7030 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000229048500069 | - |
dc.identifier.scopusid | 2-s2.0-18744371579 | - |
dc.citation.endPage | 7030 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 7026 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 102 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | endoplasmic reticulum | - |
dc.subject.keywordAuthor | glycosylation | - |
dc.subject.keywordAuthor | Lys-Asp-Glu-Leu | - |
dc.subject.keywordAuthor | mammalian-derived mAb | - |
dc.subject.keywordPlus | UNTRANSLATED LEADER SEQUENCE | - |
dc.subject.keywordPlus | HUMAN IGG-FC | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | COLORECTAL-CARCINOMA | - |
dc.subject.keywordPlus | TRANSGENIC PLANTS | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | N-GLYCOSYLATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | CARBOHYDRATE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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