흰쥐 태자의 눈 발생과정에서 형질전환성장인자 - β2 및 β3 발현의 면역조직화학적 관찰

Abstract

The expression of the transforming growth factor(TGF)-β_2 and ·β_3 was studied in the eye of fetal rats by immunohistochemistry. The results obtained were as follows. The TGF-β_2 and·β_3 expressed in almost all parts of the eye, exhibited the localization in the same areas as well as the localization specific to each isoforms, which indicated the roles of TGF-β_2 and TGF-β_3 were partly dependent on each other. TGF-β_2 showed the characteristic expression pattern in neuroepithelial layer of retina and les cell. TGF-β_3 showed characteristic expression in pigment layer of retina as well as in lens cell. TGF-β_2 exhibited strong and characteristic expression pattern and seemed to have more important role than TGF-β_3 in eye formation. In summary, the expression of TGF-β_2 and·β_3 in the development of the eye was observed in almost all parts, such as iris, lens, retina, and aqueous humor and seemed to play a role in the formation of eyes at fetal life.