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Caspases Activation in Ultraviolet B-induced Apoptosis of G361 Human Melanoma Cell line.
- Authors
- Park, Kyoung Chan; Lim, Jeong Gu; Kim, Dong Seok; Choi, Hyuk Ok; Kim, Kyu Han; Cho, Kwang Hyun; Youn, Jai Il; Eun, Hee Chual; Suh, Dae Hun
- Issue Date
- Oct-2000
- Publisher
- 대한피부과학회
- Keywords
- Melanoma cells; Ultraviolet B; Apoptosis; Caspase
- Citation
- Annals of Dermatology, v.12, no.4, pp 243 - 246
- Pages
- 4
- Journal Title
- Annals of Dermatology
- Volume
- 12
- Number
- 4
- Start Page
- 243
- End Page
- 246
- ISSN
- 1013-9087
2005-3894
- Abstract
- Background : Ultraviolet B (UVB) irradiation can induce apoptosis of melanocytes and melanoma cells. However, mechanism of UVB-induced apoptosis of melanoma cells is not clarified yet. Objective : Our purpose was to study the molecular mechanism of UVB-induced apoptosis of melanoma cells. Methods : G361 lightly pigmented melanoma cells were analyzed for apoptotic mechanism by flow cytometry and western blotting. Results : G361 melanoma cells showed apoptotic features with gradual increment of UVB doses by MTT and flow cytometry. Western blotting disclosed activation of caspase-3 and poly (ADP-ribose) polymerase (PARP) after UVB irradiation. Conclusion : In this study, we showed that UVB-induced apoptosis of melanoma cells is mediated by PARP activation which is induced by caspase cascade.
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