Ethylene Oxide Gas로 소독처리한 Acellular Allogenic Dermis의 안정성과 효용성Safety and Efficacy of Ethylene Oxide Gas Sterilized Acellular Allogenic Dermis
- Authors
- 김지욱; 김한구; 김승홍; 김우섭; 김미경
- Issue Date
- Nov-2004
- Publisher
- 대한성형외과학회
- Keywords
- SureDerm??; Ethylene Oxide gas; SureDerm??; Ethylene Oxide gas
- Citation
- Archives of Plastic Surgery, v.31, no.6, pp 873 - 879
- Pages
- 7
- Journal Title
- Archives of Plastic Surgery
- Volume
- 31
- Number
- 6
- Start Page
- 873
- End Page
- 879
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66893
- ISSN
- 2234-6163
2234-6171
- Abstract
- The human acelluar allogenic dermis has been used for soft tissue augmentation of sunken areas. Because of high price, extra-acelluar allogenic dermis is resterilized after being used. The purpose of this experiment is to evaluate the safety and efficacy of ethylene oxide (E.O) gas sterilized acellular allogenic dermal graft(Sure Derm??).Twenty-four white rats, weighing about 200 grams and of 5 weeks of age were divided into 3 groups. The prepared SureDerm?? sheets(10×10mm sized , each 1 mm in thickness) were implanted into the pockets of back area. Biopsy specimens were taken after 4, 8 and 12 weeks and examined histologically for inflammatory reaction, neocollagen synthesis. The initial volume of the graft was measured by immersing it in a 2cc of normal saline and the volume of fluid displaced was checked. The changes in graft volume were measured by the same method.There was a tiny decrease in the volume of the E.O. gas sterilized graft. However, there was no significant difference in the survival rate among the groups(p<0.05). Histological analysis demonstrated progressive monocytes and fibroblast infiltration, sparce collagen bundle organization with time in E.O. gas sterilized grafts.Our experimental study suggests that E.O. gas re- sterilized SureDerm?? might not be a safe material to use as an implant.
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