진주종과 외이도에서 PCNA의 발현Expression of PCNA in Cholesteatoma and Auditory Meatal Skin
- Authors
- Chang, Kyung Hoon; Cho, Hyun Chul; Hwang, Chang Seung; Yang, Hoon Shik; Kim, Chun Gil; Park, Eun Sub
- Issue Date
- 1996
- Publisher
- 대한이비인후과학회
- Keywords
- Cholesteatoma; PCNA
- Citation
- 대한이비인후과학회지 두경부외과학, v.39, no.11, pp 1832 - 1838
- Pages
- 7
- Journal Title
- 대한이비인후과학회지 두경부외과학
- Volume
- 39
- Number
- 11
- Start Page
- 1832
- End Page
- 1838
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67016
- ISSN
- 2092-5859
2092-6529
- Abstract
- Cholesteatoma is characterized by the presence of a squamous epithelium invading the middle ear altering its growth properties. This epithelium is belived to have hyperproliferative properties. Inflammatory stimulation of the underlying connective tissue may be reponsible for the dysregulation and abnormal proliferative feature of the keratinocytes in cholesteatoma. Comparative investigation was performed to assess the epithelial cell kinetics of cholesteatoma and auditory meatal skin. Monoclonal antibody PCNA(proliferating cell nuclear antigen) immunohistochemical staining was applied. Specimens of cholesteatoma samples (n=30) showed an average PCNA score (quotient of the PCNA positive cells and the total number of cells) of 26.6±10.1%. Auditory meatal skin (n=8) revealed an average PCNA score of 8.2±3.4%. The results of this study confirm a highly increase in the proliferation rate of cholesteatoma keratinocytes, which had an PCNA score that was 3.24 times higher than the score for keratinocyte of auditory meatal skin. Since the cholesteatoma possesses a variable degree of proliferative activities depending on its histologic composition, the formation and accumulation of the keratin due to the continuous epithelial growth probably are important element in inducing the inflammation.
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.