위선암에서의 nm23 발현에 대한 면역조직화학적 분석

Abstract

Gene expression of nm23 has been investigated in number of tumors, including breast cancer, colon cancer, malignant melanoma, and hepatocellular carcinoma. Its down-regulation has been shown to be associated with metastasis or disease progression in some of the tumors. To elucidate the role of nm23 in human gastric carcinoma, sections of formalin-fixed, paraffin-embaded tissue from 50 primary stomach cancer were stained immuno-histochemically against the nm23 protein. There was a significant down-regulation of the nm23 gene in gastric cancer with serosal invasion(T3 and T4 by TNM classification), nodal metastasis and in poorly differentiated tubular carcinoma. It was suggested that the down-regulation of nm23 gene might have a role in metastasis and invasion in gastric cancer.