The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects
DC Field | Value | Language |
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dc.contributor.author | Oh, Hyun Hee | - |
dc.contributor.author | Kim, Kil Soo | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Yang, Hyun Sung | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.accessioned | 2023-07-06T03:41:10Z | - |
dc.date.available | 2023-07-06T03:41:10Z | - |
dc.date.issued | 2004-08 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.issn | 1532-8600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67077 | - |
dc.description.abstract | Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of A-3826G polymorphism of the UCP-1 gene on the plasma lipid profiles in 190 Korean obese subjects with a body mass index (BMI) more than 30 kg /m(2). Height, weight, BMI, wait-to-hip ratio (WHR), obesity index, and body composition were measured and genotype of UCP-1 was analyzed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Serum concentrations of fasting glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. The frequencies of UCP-1 genotypes were AA type, 22.1%; AG type, 53.7%; and GG type, 24.2%; and the frequency of G allele was 0.51. Among many parameters, diastolic blood pressure (DBP) (P =.023) and low-density lipoprotein (LDL) cholesterol (P =.011) were significantly higher in AG and GG types compared with AA type, whereas HDL cholesterol was significantly lower in GG type compared with other types (P <.05). Atherogenic index was significantly higher in GG type compared with AA type (P = 0.027). LDL-to-HDL cholesterol ratio was significantly increased in the order of AA < AG < GG types (P =.001). When the subjects were divided into a normal group and a hyper-LDL cholesterolernia group by LDL cholesterol level of 3.626 mmol/L (140 mg/dL), the frequency of hyper-LDL cholesterolernia was significantly higher in GG type compared with other types by Fisher's exact (chi-square) test (P =.05). When logistic regression analysis was conducted to find the risk factors of hyper-LDL cholesterolernia, the odds ratio was 4.115 (P =.03) for GG type of UCP-1 gene. These results suggest that the GG type of the UCP-1 gene has a strong association with increased LDL cholesterol level and might be a significant risk factor for hyper-LDL cholesterolernia among Korean obese subjects. (C) 2004 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W B SAUNDERS CO | - |
dc.title | The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.metabol.2004.02.014 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.53, no.8, pp 1054 - 1059 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000223314300019 | - |
dc.identifier.scopusid | 2-s2.0-3342964198 | - |
dc.citation.endPage | 1059 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1054 | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 53 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | BETA(3)-ADRENERGIC RECEPTOR GENES | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DNA POLYMORPHISM | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | WEIGHT-GAIN | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | BODY-FAT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordPlus | VARIANT | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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