The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects
- Authors
- Oh, Hyun Hee; Kim, Kil Soo; Choi, Sun Mi; Yang, Hyun Sung; Yoon, Yoosik
- Issue Date
- Aug-2004
- Publisher
- W B SAUNDERS CO
- Citation
- METABOLISM-CLINICAL AND EXPERIMENTAL, v.53, no.8, pp 1054 - 1059
- Pages
- 6
- Journal Title
- METABOLISM-CLINICAL AND EXPERIMENTAL
- Volume
- 53
- Number
- 8
- Start Page
- 1054
- End Page
- 1059
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67077
- DOI
- 10.1016/j.metabol.2004.02.014
- ISSN
- 0026-0495
1532-8600
- Abstract
- Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of A-3826G polymorphism of the UCP-1 gene on the plasma lipid profiles in 190 Korean obese subjects with a body mass index (BMI) more than 30 kg /m(2). Height, weight, BMI, wait-to-hip ratio (WHR), obesity index, and body composition were measured and genotype of UCP-1 was analyzed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Serum concentrations of fasting glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. The frequencies of UCP-1 genotypes were AA type, 22.1%; AG type, 53.7%; and GG type, 24.2%; and the frequency of G allele was 0.51. Among many parameters, diastolic blood pressure (DBP) (P =.023) and low-density lipoprotein (LDL) cholesterol (P =.011) were significantly higher in AG and GG types compared with AA type, whereas HDL cholesterol was significantly lower in GG type compared with other types (P <.05). Atherogenic index was significantly higher in GG type compared with AA type (P = 0.027). LDL-to-HDL cholesterol ratio was significantly increased in the order of AA < AG < GG types (P =.001). When the subjects were divided into a normal group and a hyper-LDL cholesterolernia group by LDL cholesterol level of 3.626 mmol/L (140 mg/dL), the frequency of hyper-LDL cholesterolernia was significantly higher in GG type compared with other types by Fisher's exact (chi-square) test (P =.05). When logistic regression analysis was conducted to find the risk factors of hyper-LDL cholesterolernia, the odds ratio was 4.115 (P =.03) for GG type of UCP-1 gene. These results suggest that the GG type of the UCP-1 gene has a strong association with increased LDL cholesterol level and might be a significant risk factor for hyper-LDL cholesterolernia among Korean obese subjects. (C) 2004 Elsevier Inc. All rights reserved.
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