누드 마우스에 이종이식된 인형 위암 세포주에서 Meloxicam이 종양의 성장과 혈관 신생에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong Jin | - |
dc.contributor.author | Sim, Woo Jung | - |
dc.contributor.author | Cha, Sung Jae | - |
dc.contributor.author | Chi, Kyong Chun | - |
dc.contributor.author | Park, Sung Jun | - |
dc.contributor.author | Lim, Hyun Muck | - |
dc.contributor.author | Park, Sung Il | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Park, Won Sub | - |
dc.date.accessioned | 2023-07-28T06:40:36Z | - |
dc.date.available | 2023-07-28T06:40:36Z | - |
dc.date.issued | 2001-11 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.issn | 2288-6796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67297 | - |
dc.description.abstract | Purpose : In general, tumor growth is dependent on angiogenesis. COX, known as modulator of angiogenesis, consists of two at least isozymes constitutive COX-1 and stress-induced COX-2. The latter is known in case of gastric cancer to be overexpressed in neoplastic tissue but not in adjacent normal tissue. To clarify the effect of COX-2 inhibitors on tumor growth and angiogenesis, we investigated the effects of Meloxicam (a selective COX-2 inhibitor) on gastric cancer xenograft in nude mise that overexpress COX-2. Methods : MKN45 gastric cancer cell lines that overexpress COX-2 were inoculated subcutaneously into athymic mice. The mean tumor volume, apoptotic index, proliferative index, microvessel count and angiogenic factors (VEGF and bFGF) were measured in the control group (12 cases) and the meloxicam treated group (23 cases). Results : There was no significant difference of COX-2 expression between the control and meloxicam treated groups in mRNA level as measured by RT-PCR, nor in protein level by Western blotting. However, in the meloxicam treated group, apoptosis was increased to a statistically significant degree (P<0.01) while the proliferation index as measured by Ki-67, the mean tumor volume and angiogenesis were all significantly decreased, as compared with the control group (P<0.01). Conclusion : The possible suppression of angiogenesis and tumor growth in gastric cancer xenograft by meloxicam suggests potentially. Novel and promising applications of COX-2 inhibitors in the adjuvant treatment of gastric cancer. However, further clinical study will be needed to determine its efficacy in such treatment modalities | - |
dc.format.extent | 9 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한외과학회 | - |
dc.title | 누드 마우스에 이종이식된 인형 위암 세포주에서 Meloxicam이 종양의 성장과 혈관 신생에 미치는 영향 | - |
dc.title.alternative | The effect of meloxicam on tumor growth and angiogenesis of human gastric cancer cell line xenograft in nude mice | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한외과학회지, v.61, no.5, pp 465 - 473 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 473 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 465 | - |
dc.citation.title | 대한외과학회지 | - |
dc.citation.volume | 61 | - |
dc.identifier.url | https://kmbase.medric.or.kr/KMID/0371320010610050465 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | Meloxicam | - |
dc.subject.keywordAuthor | 위암 | - |
dc.subject.keywordAuthor | 혈관신생 | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | Meloxicam | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.description.journalRegisteredClass | domestic | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.