누드 마우스에 이종이식된 인형 위암 세포주에서 Meloxicam이 종양의 성장과 혈관 신생에 미치는 영향The effect of meloxicam on tumor growth and angiogenesis of human gastric cancer cell line xenograft in nude mice
- Authors
- Lee, Yong Jin; Sim, Woo Jung; Cha, Sung Jae; Chi, Kyong Chun; Park, Sung Jun; Lim, Hyun Muck; Park, Sung Il; Lee, Tae Jin; Park, Won Sub
- Issue Date
- Nov-2001
- Publisher
- 대한외과학회
- Keywords
- COX-2; Meloxicam; 위암; 혈관신생; COX-2; Meloxicam; Gastric cancer; Angiogenesis
- Citation
- 대한외과학회지, v.61, no.5, pp 465 - 473
- Pages
- 9
- Journal Title
- 대한외과학회지
- Volume
- 61
- Number
- 5
- Start Page
- 465
- End Page
- 473
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67297
- ISSN
- 2288-6575
2288-6796
- Abstract
- Purpose : In general, tumor growth is dependent on angiogenesis. COX, known as modulator of angiogenesis, consists of two at least isozymes constitutive COX-1 and stress-induced COX-2. The latter is known in case of gastric cancer to be
overexpressed in neoplastic tissue but not in adjacent normal tissue. To clarify the effect of COX-2 inhibitors on tumor growth and angiogenesis, we investigated the effects of Meloxicam (a selective COX-2 inhibitor) on gastric cancer xenograft
in
nude
mise that overexpress COX-2.
Methods : MKN45 gastric cancer cell lines that overexpress COX-2 were inoculated subcutaneously into athymic mice. The mean tumor volume, apoptotic index, proliferative index, microvessel count and angiogenic factors (VEGF and bFGF) were
measured
in the control group (12 cases) and the meloxicam treated group (23 cases).
Results : There was no significant difference of COX-2 expression between the control and meloxicam treated groups in mRNA level as measured by RT-PCR, nor in protein level by Western blotting. However, in the meloxicam treated group,
apoptosis
was increased to a statistically significant degree (P<0.01) while the proliferation index as measured by Ki-67, the mean tumor volume and angiogenesis were all significantly decreased, as compared with the control group (P<0.01).
Conclusion : The possible suppression of angiogenesis and tumor growth in gastric cancer xenograft by meloxicam suggests potentially. Novel and promising applications of COX-2 inhibitors in the adjuvant treatment of gastric cancer.
However,
further clinical study will be needed to determine its efficacy in such treatment modalities
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