위선암종에서 p53 및 MDM-2단백 발현과 임상병리학적 인자들과의 상관관계Expression of MDM - 2 and p53 Proteins in Gastric Adenocarcinoma and Its Relationship with Clinicopathologic Factors
- Authors
- Yang, Ji Woong; Kim, Hyoung Joong; Lee, Tae Jin; Park, Eon Sub; Yoo, Jae Hyung
- Issue Date
- Jan-2000
- Publisher
- 대한암학회
- Keywords
- p53 protein; Murine double minute-2 protein; Stomach neoplasm
- Citation
- Cancer Research and Treatment, v.32, no.3, pp 474 - 486
- Pages
- 13
- Journal Title
- Cancer Research and Treatment
- Volume
- 32
- Number
- 3
- Start Page
- 474
- End Page
- 486
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67302
- ISSN
- 1598-2998
2005-9256
- Abstract
- Purpose :MDM-2 is an oncoprotein that inhibits p53 tumor-suppressor protein. These abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognostic value of MDM2 abnormalities in gastric adenocarcinoma, MDM2 & p53 protein expression were analysed in surgically resected materials of gastric adenocarcinoma.
Materials and Methods :Fifty cases which had got follow-up after surgical resection were immunohistochemically studied with p53 and MDM-2 antibodies. We defined variable clinicopathologic factors for expression of p53 and MDM-2 protein and analysed their relationships.
Results :Immunohistochemical stain revealed expression of MDM-2 protein as a 52.0% (26/50) and p53 protein 20.0% (10/50), respectively. But their expressions were not associated with clinicopathological factors such as T-factor, N-factor, stage, histology and differentiation. Overall, p53-negative patients seemed to have a better prognosis regardless of MDM-2 protein status (P=0.057). MDM-2 protein was considered to have no play as a prognostic factor.
Conclusion :In the gastric adenocarcinoma, p53 protein expression seemed to have a inverse relationship with clinical outcomes but MDM-2 protein expression, which was observed more frequently than those of p53, seemed not to be prognostic indicator.
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