Prenatal screening for neural tube defects: from maternal serum alpha-fetoprotein to ultrasonography
- Authors
- Kim, Gwang Jun; Seong, J.S.; Oh, J.A.
- Issue Date
- Jan-2023
- Publisher
- 대한산부인과학회
- Keywords
- Neural tube defects; Alpha-fetoprotein; Ultrasonography
- Citation
- Obstetrics & Gynecology Science, v.66, no.1, pp 1 - 10
- Pages
- 10
- Journal Title
- Obstetrics & Gynecology Science
- Volume
- 66
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68084
- DOI
- 10.5468/ogs.22263
- ISSN
- 2287-8580
2287-8580
- Abstract
- The two main screening tests during pregnancy are those for chromosomal abnormalities and neural tube defects(NTDs). In particular, for NTDs, measurement of maternal serum alpha-fetoprotein (MSAFP) levels early in the secondtrimester (15-18 weeks of gestation) has been considered the gold standard screening test for the past 4 decades.
However, with remarkable technological advancements and the widespread use of ultrasound during those periods,mid-trimester ultrasonography has gradually replaced the role of measuring MSAFP levels as a screening method forNTDs. This change was initiated more about 10 years ago in some countries, which have issued national guidelinesto use mid-trimester ultrasonography instead of measuring MSAFP levels as a prenatal screening method for NTDs.
However, no significant changes have occurred in Korea, where second-trimester ultrasonography is routinelyperformed with high-quality equipment. We aimed to provide information regarding the importance of changing thescreening method for NTDs from MSAFP measurement to ultrasonography, and to detail methods of implementingmid-trimester ultrasonography for screening purposes. We also share our experience of operating a prenataldiagnostic program for NTDs without using MSAFP for more than 15 years.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68084)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.