Sex-specific risk factors associated with graves’ orbitopathy in Korean patients with newly diagnosed graves’ disease
DC Field | Value | Language |
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dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kang, J. | - |
dc.contributor.author | Ahn, H.Y. | - |
dc.contributor.author | Lee, J.K. | - |
dc.date.accessioned | 2023-10-24T01:41:17Z | - |
dc.date.available | 2023-10-24T01:41:17Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0950-222X | - |
dc.identifier.issn | 1476-5454 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68243 | - |
dc.description.abstract | Objective: To assess sex-specific risk factors for Graves’ orbitopathy (GO) in newly diagnosed Graves’ disease (GD) patients. Methods: A retrospective cohort study was conducted using the National Health Insurance Service’s sample database, which consisted of 1,137,861 subjects from 2002 to 2019. The international classification of disease-10 codes was used to identify those who developed GD (E05) and GO (H062). A multivariable Cox proportional hazards model was used to estimate the effect of risk factors on GO development. Results: Among 2145 male and 5047 female GD patients, GO occurred in 134 men (6.2%) and 293 women (5.8%). A multivariable Cox regression model revealed that GO development was significantly associated with younger age (HR = 0.84, 95% CI = 0.73–0.98), low income (HR = 0.55, 95% CI = 0.35–0.86), and heavy drinking (HR = 1.79, 95% CI = 1.10–2.90) in men, and with younger age (HR = 0.89, 95% CI = 0.81–0.98), lower body mass index (HR = 0.55, 95% CI = 0.33–0.90), high total cholesterol (HR = 1.04, 95% CI = 1.01–1.06), hyperlipidaemia (HR = 1.37, 95% CI = 1.02–1.85), and lower statin dose (HR = 0.37, 95% CI = 0.22–0.62) in women. There was no association between smoking and GO development in both men and women. Conclusions: The risk factors for GO development were sex-dependent. These results show the need for more sophisticated attention and support considering sex characteristics in GO surveillance. © 2023, The Author(s). | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Nature | - |
dc.title | Sex-specific risk factors associated with graves’ orbitopathy in Korean patients with newly diagnosed graves’ disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41433-023-02513-z | - |
dc.identifier.bibliographicCitation | Eye (Basingstoke), v.37, no.16, pp 3382 - 3391 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000969138300003 | - |
dc.identifier.scopusid | 2-s2.0-85152368259 | - |
dc.citation.endPage | 3391 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 3382 | - |
dc.citation.title | Eye (Basingstoke) | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | THYROID-ASSOCIATED OPHTHALMOPATHY | - |
dc.subject.keywordPlus | MULTIPLE IMPUTATION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | SMOKING | - |
dc.subject.keywordPlus | AGE | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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