Prediction of amyloid PET positivity via machine learning algorithms trained with EDTA-based blood amyloid-beta oligomerization dataopen access
- Authors
- Youn, Young Chul; Kim, Hye Ryoun; Shin, Hae-Won; Jeong, Hae-Bong; Han, Sang-Won; Pyun, Jung-Min; Ryoo, Nayoung; Park, Young Ho; Kim, Sang Yun
- Issue Date
- Nov-2022
- Publisher
- BMC
- Keywords
- Machine learning; Oligomer; Amyloid ss; Alzheimer's disease; Biomarker; Multimer detection system; Amyloid positron emission tomography
- Citation
- BMC MEDICAL INFORMATICS AND DECISION MAKING, v.22, no.1
- Journal Title
- BMC MEDICAL INFORMATICS AND DECISION MAKING
- Volume
- 22
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68444
- DOI
- 10.1186/s12911-022-02024-z
- ISSN
- 1472-6947
1472-6947
- Abstract
- Background The tendency of amyloid-beta to form oligomers in the blood as measured with Multimer Detection System-Oligomeric Amyloid-beta (MDS-OA beta) is a valuable biomarker for Alzheimer's disease and has been verified with heparin-based plasma. The objective of this study was to evaluate the performance of ethylenediaminetetraacetic acid (EDTA)-based MDS-OA beta and to develop machine learning algorithms to predict amyloid positron emission tomography (PET) positivity. Methods The performance of EDTA-based MDS-OA beta in predicting PET positivity was evaluated in 312 individuals with various machine learning models. The models with various combinations of features (i.e., MDS-OA beta level, age, apolipoprotein E4 alleles, and Mini-Mental Status Examination [MMSE] score) were tested 50 times on each dataset. Results The random forest model best-predicted amyloid PET positivity based on MDS-OA beta combined with other features with an accuracy of 77.14 +/- 4.21% and an F1 of 85.44 +/- 3.10%. The order of significance of predictive features was MDS-OA beta, MMSE, Age, and APOE. The Support Vector Machine using the MDS-OA beta value only showed an accuracy of 71.09 +/- 3.27% and F-1 value of 80.18 +/- 2.70%. Conclusions The Random Forest model using EDTA-based MDS-OA beta combined with the MMSE and apolipoprotein E status can be used to prescreen for amyloid PET positivity.
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