Cycloastragenol inhibits adipogenesis and fat accumulation in vitro and in vivo through activating Hedgehog signaling
- Authors
- Kim, Jin Tae; Chen, Jing; Zhou, Yimeng; Son, Moon Jeong; Jeon, Dong Hyeon; Kwon, Jung Won; Lee, Ga Yeon; Lee, Hong Jin
- Issue Date
- Feb-2024
- Publisher
- The Korean Society of Food Science and Technology
- Keywords
- Adipogenesis; Adipogenesis-related transcription factor; Cycloastragenol; Gli1; Hedgehog signaling
- Citation
- Food Science and Biotechnology, v.33, no.3, pp 711 - 720
- Pages
- 10
- Journal Title
- Food Science and Biotechnology
- Volume
- 33
- Number
- 3
- Start Page
- 711
- End Page
- 720
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68550
- DOI
- 10.1007/s10068-023-01403-0
- ISSN
- 1226-7708
2092-6456
- Abstract
- In this study, we investigated the effect of cycloastragenol (CAG), a triterpenoid isolated from Astragalus membranaceus roots, on regulating the adipogenesis and fat accumulation in vitro and in vivo. During the adipogenesis of 3T3-L1 cells, CAG inhibited lipid accumulation and the expression of key adipogenic factors, proliferator-activated receptor γ (PPARγ) and CCAAT enhancer binding protein α (C/EBPα) and increased the expression of Gli1, a key mediator in Hedgehog (Hh) signaling. In HFD-induced animal experiment, CAG significantly reduced body weight gain without affecting brown fat weight. In addition, CAG regulated the expression of PPARγ, C/EBPα, and Gli1 in visceral white adipose tissue (vWAT). We also confirmed the inhibitory effect of CAG on specifically targeting white adipose tissue (WAT) formation in stromal vascular fraction (SVF) cell differentiation. Taken together, these results suggest that CAG may be a potent phytochemical preventing adipogenesis and obesity via Hh signaling. © 2023, The Korean Society of Food Science and Technology.
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