Perilla oil and α-linolenic acid ameliorated thrombosis in rats induced by collagen and epinephrine
- Authors
- Kim, Jin Tae; Lee, Seung Beom; Son, Moon Jeong; Zhou, Yimeng; Qiu, Shuai; Park, Ho Jin; Jeon, Dong Hyeon; Kim, Young-Jun; Lee, Hong Jin
- Issue Date
- Jun-2023
- Publisher
- The Korean Society of Food Science and Technology
- Keywords
- Cells adhesion molecules; Collagen and epinephrine; Perilla oil; Thrombosis; α-Linolenic acid
- Citation
- Food Science and Biotechnology, v.32, no.7, pp 997 - 1003
- Pages
- 7
- Journal Title
- Food Science and Biotechnology
- Volume
- 32
- Number
- 7
- Start Page
- 997
- End Page
- 1003
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68558
- DOI
- 10.1007/s10068-022-01241-6
- ISSN
- 1226-7708
2092-6456
- Abstract
- Perilla frutescens is an annual herbaceous plant widely cultivated for oil production in China, Japan, and Korea. In this study, we investigated the effect of perilla oil (PO) on thrombosis induced by collagen and epinephrine (CE) in rats. The oral administration of PO significantly increased prothrombin time (PT) and activated partial thromboplastin time (aPTT) in the blood plasma and inhibited the expression of cells adhesion markers (CAMs) such as intercellular CAM-1 (ICAM-1), vascular CAM (VCAM-1), E-selectin and P-selectin in the aorta tissue. Furthermore, pulmonary occlusion induced by CE in rats was suppressed by PO. α-Linolenic acid (ALA) was quantified at 60.14 ± 2.50 g/100 g of PO, and its oral administration at the same concentration with that in PO exerted the similar effect on PT, aPTT, ICAM-1, VCAM-1, E-selectin and P-selectin in CE-induced thrombosis rats. Taken together, PO and ALA significantly ameliorated thrombosis by regulating CAMs. © 2023, The Korean Society of Food Science and Technology.
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