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Modulation of inflammation-induced cytokine production and complement activity of biopolymers extracted from medicinal plants

Authors
Jeong, Sang ChulKoyyalamudi, Sundar RaoHughes, J.MargaretKhoo, CheangBailey, TrevorPark, Jong PilSong, Chi Hyun
Issue Date
2013
Keywords
Endo-polysaccharide; ENP; Anti-inflammatory; Cytokines; Complement
Citation
Phytopharmacology, v.4, no.1, pp 19 - 30
Pages
12
Journal Title
Phytopharmacology
Volume
4
Number
1
Start Page
19
End Page
30
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68574
Abstract
This study evaluates the anti-inflammatory activities of the extracts obtained from the medicinal plants Aster tataricus, Pinellia ternata, Ostericum koreanum, Platicodon grandiflorum, Asarum sieboldii, Tussilage farfara, and Acanthopanax sessiliflorus. These plants are used in Korea to treat inflammatory and respiratory ailments, including asthma. The hot water extract (HWE) of A. sessiliflorus inhibited production of IFN-γ, IL-2, IL-4 and IL-5. The HWE of A. tataricus, O. koreanum, P. grandiflorum, A. sieboldii and T. farfara had similar inhibitory effects on IFN-γ and IL-5. The endo-polysaccharide (ENP) screened were less active than the HWE and had varying effects on the production of cytokines. The HWE fractions from all the plants except that from P. grandiflorum had marked anti-complement activity at a concentration of 1000 g/ml. The ENP of A. sieboldii, T. farfara and A. sessiliflorus exhibited significant anti-complement activity compared to the positive control.
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대학원 (식품생명공학과)
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