Expression of interferon-gamma and tumour necrosis factor-alpha in pigs experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV)
DC Field | Value | Language |
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dc.contributor.author | Choi, C | - |
dc.contributor.author | Cho, WS | - |
dc.contributor.author | Kim, B | - |
dc.contributor.author | Chae, C | - |
dc.date.accessioned | 2023-12-01T08:44:07Z | - |
dc.date.available | 2023-12-01T08:44:07Z | - |
dc.date.issued | 2002-08 | - |
dc.identifier.issn | 0021-9975 | - |
dc.identifier.issn | 1532-3129 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68758 | - |
dc.description.abstract | The expression of mRNA encoding interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of PRRSV. Both IFN-gamma and TNF-alpha mRNA were detected in the lung as early as 1 day post-inoculation (dpi) and up to 10 dpi. Hybridization signals for IFN-gamma and TNF-alpha were usually associated with inflammation, in particular with macrophages within alveolar septa. Expression of these cytokines was minimal in non-lesional lung of PRRSV-infected pigs and in normal lung from control pigs. The results suggest that IFN-gamma and TNF-alpha play a role in pulmonary defence against PRRSV. (C) 2002 Elsevier Science Ltd. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD | - |
dc.title | Expression of interferon-gamma and tumour necrosis factor-alpha in pigs experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1053/jcpa.2002.0566 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COMPARATIVE PATHOLOGY, v.127, no.2-3, pp 106 - 113 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000178368000003 | - |
dc.identifier.scopusid | 2-s2.0-0036696796 | - |
dc.citation.endPage | 113 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 106 | - |
dc.citation.title | JOURNAL OF COMPARATIVE PATHOLOGY | - |
dc.citation.volume | 127 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | POLYMERASE CHAIN-REACTION | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | LELYSTAD-VIRUS | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | PIGLETS | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | STILLBORN | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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