Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens
DC Field | Value | Language |
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dc.contributor.author | Lee, Dong Gu | - |
dc.contributor.author | Mok, So-Youn | - |
dc.contributor.author | Choi, Changsun | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Kim,Hyun Young | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.date.accessioned | 2023-12-05T00:40:10Z | - |
dc.date.available | 2023-12-05T00:40:10Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 2325-7458 | - |
dc.identifier.issn | 2325-744X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/68816 | - |
dc.description.abstract | To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications. | - |
dc.format.extent | 6 | - |
dc.title | Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens | - |
dc.type | Article | - |
dc.identifier.doi | 10.4236/jacen.2012.11005 | - |
dc.identifier.bibliographicCitation | Journal of Agricultural Chemistry and Environment, v.1, no.1, pp 28 - 33 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | Journal of Agricultural Chemistry and Environment | - |
dc.citation.volume | 1 | - |
dc.subject.keywordAuthor | Blumea balsamifera | - |
dc.subject.keywordAuthor | Apigenin | - |
dc.subject.keywordAuthor | Aldose Reductase Inhibition | - |
dc.subject.keywordAuthor | HPLC | - |
dc.description.journalRegisteredClass | foreign | - |
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