Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activityopen access
- Authors
- Shin, Seung Yong; Kim, Hee Sung; Kim, Kisung; Choi, Chang Won; Moon, Jung Min; Kim, Jeong Wook; Joo, Hyun Jin; Seo, Jeongkuk; Sung, Muhyeon; Choi, Chang Hwan
- Issue Date
- Jan-2024
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Ulcerative colitis; Histology; Endoscopy; Prognosis
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.39, no.1, pp 68 - 76
- Pages
- 9
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 39
- Number
- 1
- Start Page
- 68
- End Page
- 76
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69247
- DOI
- 10.3904/kjim.2023.167
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH).Methods: We prospectively collected and reviewed data from patients with UC who underwent colonoscopy or sigmoidoscopy with biopsy. Complete and partial MH were defined as Mayo endoscopic subscores (MESs) of 0 and 1, respectively. Histologic variables, including the Nancy index (NI), predicting disease progression (defined as the need for medication upgrade or hospitalization/surgery), were evaluated and correlated with endoscopic findings.Results: Overall, 441 biopsy specimens were collected from 194 patients. The average follow-up duration was 14.7 +/- 7.4 months. There were 49 (25.3%) and 68 (35.1%) patients with MESs of 0 and 1, respectively. Disease progression occurred only in patients with an MES of 1. NI >= 3 was significantly correlated with disease progression during follow-up. Mucosal friability on endoscopy was significantly correlated with NI >= 3 (61.1% in NI < 3 vs. 88.0% in NI >= 3; p = 0.013).Conclusions: Histological activity can help predict the prognosis of patients with UC with mild endoscopic activity. Mucosal friability observed on endoscopy may reflect a more severe histological status, which can be a risk factor for disease progression.
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