Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation
- Authors
- Choi, Mi-Hyun; Kim, Hyung-Sik; Gim, Seon-Young; Kim, Woo-Ram; Mun, Kyung-Ryul; Tack, Gye-Rae; Lee, Bongsoo; Choi, Young Chil; Kim, Hyun-Jun; Hong, Seung Hwa; Lim, Dae-Woon; Chung, Soon-Cheol
- Issue Date
- May-2016
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Cognitive ability; Hippocampal volume; Alzheimer disease; Amnestic mild cognitive impairment; Boston naming test
- Citation
- NEUROSCIENCE LETTERS, v.620, pp 115 - 120
- Pages
- 6
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 620
- Start Page
- 115
- End Page
- 120
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6943
- DOI
- 10.1016/j.neulet.2016.03.044
- ISSN
- 0304-3940
1872-7972
- Abstract
- The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal volume. These results will be helpful for choosing an accurate and economically feasible test method that efficiently differentiates the three groups. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Energy System Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6943)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.