Effects of gypenoside L-containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double-blind, placebo-controlled, randomized trial
- Authors
- Ahn, Yejin; Lee, Hee-Seok; Lee, Seok-Hee; Joa, Kyung-Lim; Lim, Cho Young; Ahn, Yu Jin; Suh, Hyung Joo; Park, Sung-Soo; Hong, Ki-Bae
- Issue Date
- Jul-2023
- Publisher
- WILEY
- Keywords
- clinical trial; cognitive fatigue; exercise performance; Gynostemma pentaphyllum; gypenoside L
- Citation
- PHYTOTHERAPY RESEARCH, v.37, no.7, pp 3069 - 3082
- Pages
- 14
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 37
- Number
- 7
- Start Page
- 3069
- End Page
- 3082
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69566
- DOI
- 10.1002/ptr.7801
- ISSN
- 0951-418X
1099-1573
- Abstract
- This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19-60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety-related parameters were compared between the two groups. Maximal oxygen consumption (VO2 max) and O-2 pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise-induced physical and mental fatigue.
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