Biomechanical forces in the aged brain: Relationship to ADopen access
- Authors
- Lee, Gyeong Yun; Kim, Ok-Hyeon; Kim, Eun Ran; Lee, Hyun Jung
- Issue Date
- Jan-2023
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Microenvironment; Biomechanical cues; Aging; Brain; Alzheimer's disease
- Citation
- LIFE SCIENCES, v.312
- Journal Title
- LIFE SCIENCES
- Volume
- 312
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69691
- DOI
- 10.1016/j.lfs.2022.121237
- ISSN
- 0024-3205
1879-0631
- Abstract
- The pathogenesis of neurodegenerative disorders, including Alzheimer's disease, has been studied with a focus on biochemical mechanisms, such as the amyloid-beta plaque deposition and removal. Recently, the importance of brain microenvironmental cues, which comprise the sophisticated cellular and fluid system, has been emphasized in the aged brain or in pathological conditions. Especially, substrate rigidity and biomechanical forces of the brain microenvironment determine the function of glial cells and neurons; furthermore, these microenvironmental cues change with age. However, our understanding of role of the biomechanical cues on glial cells and neurons is relatively poor. In this review, we briefly introduce an overview of biomechanical forces that present in the aged brain and its sensations, and then examine the brain in Alzheimer's disease, which constitutes a representative neurodegenerative disorder, with regard to changes in the biomechanical forces associated with disease and aging.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69691)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.