Wnt5a, Ryk and Ror2 expression in glioblastoma subgroups
- Authors
- Kim, Yuil; Hong, Mineui; Do, In-Gu; Ha, Sang Yun; Lee, Dakeun; Suh, Yeon-Lim
- Issue Date
- 2015
- Publisher
- ELSEVIER GMBH
- Keywords
- Wnt5a; Ryk; Ror2; beta-Catenin; Glioblastoma
- Citation
- PATHOLOGY RESEARCH AND PRACTICE, v.211, no.12, pp 963 - 972
- Pages
- 10
- Journal Title
- PATHOLOGY RESEARCH AND PRACTICE
- Volume
- 211
- Number
- 12
- Start Page
- 963
- End Page
- 972
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69740
- DOI
- 10.1016/j.prp.2015.10.001
- ISSN
- 0344-0338
1618-0631
- Abstract
- Background: Wnt5a, a non-canonical Wnt ligand, has been shown to play tumor-promoting or tumor-suppressive roles in different neoplasms. Increased Wnt5a expression and Wnt5a-dependent invasive activity that is mediated by one of its receptors, Ryk, have been reported in glioblastomas. Methods: We investigated the protein expression of Wnt5a, its receptors Ryk and Ror2, and the canonical Wnt pathway marker P-catenin in 186 cases of glioblastoma and its variants. Associations with clinicopathological and molecular variables and prognosis were analyzed. Results: All glioblastoma cases expressed Wnt5a, Ryk and Ror2 with a different grade. The expression of both Ryk and Ror2 correlated with that of Wnt5a in glioblastomas. The expression of p-catenin did not correlate with any of Wnt5a, Ryk or Ror2. Wnt5a expression was significantly different among subgroups of the glioblastoma. However, none of Wnt5a, Ryk or Ror2 had a prognostic impact on glioblastoma. For P-catenin, a shorter progression-free survival was noted in the glioblastoma with oligodendroglioma component (GBMO) subgroup. Conclusions: Our results corroborated previous findings of Rylc-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma. (C) 2015 Elsevier GmbH. All rights reserved.
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