Ground-State Conditions Promote Robust Prdm14 Reactivation and Maintain an Active Dlk1-Dio3 Region during Reprogramming
DC Field | Value | Language |
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dc.contributor.author | Habib, Omer | - |
dc.contributor.author | Habib, Gizem | - |
dc.contributor.author | Moon, Sung-Hwan | - |
dc.contributor.author | Hong, Ki-Sung | - |
dc.contributor.author | Do, Jeong Tae | - |
dc.contributor.author | Choi, Youngsok | - |
dc.contributor.author | Chang, Sung Woon | - |
dc.contributor.author | Chung, Hyung-Min | - |
dc.date.accessioned | 2024-01-09T03:32:00Z | - |
dc.date.available | 2024-01-09T03:32:00Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69846 | - |
dc.description.abstract | Induced pluripotent stem cells (iPSCs) are capable of unlimited self-renewal and can give rise to all three germ layers, thereby providing a new platform with which to study mammalian development and epigenetic reprogramming. However, iPSC generation may result in subtle epigenetic variations, such as the aberrant methylation of the Dlk1-Dio3 locus, among the clones, and this heterogeneity constitutes a major drawback to harnessing the full potential of iPSCs. Vitamin C has recently emerged as a safeguard to ensure the normal imprinting of the Dlk1-Dio3 locus during reprogramming. Here, we show that vitamin C exerts its effect in a manner that is independent of the reprogramming kinetics. Moreover, we demonstrate that reprogramming cells under 2i conditions leads to the early upregulation of Prdm14, which in turn results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1-Dio3 locus. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Ground-State Conditions Promote Robust Prdm14 Reactivation and Maintain an Active Dlk1-Dio3 Region during Reprogramming | - |
dc.type | Article | - |
dc.identifier.doi | 10.14348/molcells.2014.2212 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.1, pp 31 - 35 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000342559100005 | - |
dc.identifier.scopusid | 2-s2.0-84901407054 | - |
dc.citation.endPage | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | 2i conditions | - |
dc.subject.keywordAuthor | Dlk1-Dio3 | - |
dc.subject.keywordAuthor | induced pluripotent stem cells | - |
dc.subject.keywordAuthor | Prdm14 | - |
dc.subject.keywordPlus | PLURIPOTENT STEM-CELLS | - |
dc.subject.keywordPlus | NAIVE PLURIPOTENCY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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