Enhancing therapeutic efficacy of photothermal therapy using poloxamer-reduced graphene oxide and mesenchymal stem cells
- Authors
- Park, Jung Hwan; Yoon, Jeong-Kee; Kim, Yu-Jin; Lee, Tae-Jin; Jeong, Gun-Jae; Kim, Dong-Ik; Bhang, Suk Ho
- Issue Date
- Dec-2019
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Human mesenchymal stem cell; Photothermal cancer therapy; Poloxamer-reduced graphene oxide
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.80, pp 846 - 853
- Pages
- 8
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 80
- Start Page
- 846
- End Page
- 853
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70013
- DOI
- 10.1016/j.jiec.2019.07.031
- ISSN
- 1226-086X
1876-794X
- Abstract
- Due to their heat-generating property based on exogenous energy irradiation, reduced graphene oxide particles (RGOs) have been widely used for photothermal cancer therapy. They show high absorbance for the near-infrared wavelength that is suitable for in vivo experimentation. However, enhancing the tumor-targeting efficiency and avoiding the self-aggregation of RGO to maximize the photothermal effect remain challenging. We demonstrated here that human mesenchymal stem cells (hMSCs) can deliver poloxamer conjugated RGOs (pRGOs) to target tumors. Self-aggregation limits cellular uptake and induces treatment of high particle concentrations for the photothermal effect. However, compared to RGOs, pRGOs did not show any self-aggregation. pRGOs-laden hMSCs injected intravenously to tumor-bearing mice led to significantly enhanced tumor-targeting efficiency and higher heat generation than injections of RGOs following exogenous laser irradiation. This work shows that the tumor tropism of hMSC can be applied for increased tumor-targeting efficiency with small amounts of particles. Taken together, the results indicate that combining hMSCs with pRGOs could increase the therapeutic effect in photothermal cancer therapy in a synergistic manner. (C) 2019 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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