Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance
- Authors
- Kim, Dae-Hyun; Lee, Jung Bok; Kang, Mi-Lan; Park, Ji Hwan; You, Jin; Yu, SeongMi; Park, Ju Young; Ryu, Seung Bae; Seon, Gyeung Mi; Yoon, Jeong-Kee; Lee, Mi Hee; Shin, Young Min; Park, Ki Dong; Park, Jong-Chul; Jang, Woo Soon; Kim, Won Shik; Sung, Hak-Joon
- Issue Date
- Nov-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- microneedles; vascular anastomosis; tubular construct; cytocompatibility; heparin coating
- Citation
- ACS BIOMATERIALS SCIENCE & ENGINEERING, v.4, no.11, pp 3848 - 3853
- Pages
- 6
- Journal Title
- ACS BIOMATERIALS SCIENCE & ENGINEERING
- Volume
- 4
- Number
- 11
- Start Page
- 3848
- End Page
- 3853
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70018
- DOI
- 10.1021/acsbiomaterials.8b01097
- ISSN
- 2373-9878
- Abstract
- To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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