Enhanced Bone Repair by Guided Osteoblast Recruitment Using Topographically Defined Implantopen access
- Authors
- Yoon, Jeong-Kee; Kim, Hong Nam; Bhang, Suk Ho; Shin, Jung-Youn; Han, Jin; La, Wan-Geun; Jeong, Gun-Jae; Kang, Seokyung; Lee, Ju-Ro; Oh, Jaesur; Kim, Min Sung; Jeon, Noo Li; Kim, Byung-Soo
- Issue Date
- Apr-2016
- Publisher
- MARY ANN LIEBERT, INC
- Citation
- TISSUE ENGINEERING PART A, v.22, no.7-8, pp 654 - 664
- Pages
- 11
- Journal Title
- TISSUE ENGINEERING PART A
- Volume
- 22
- Number
- 7-8
- Start Page
- 654
- End Page
- 664
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70028
- DOI
- 10.1089/ten.tea.2015.0417
- ISSN
- 1937-3341
1937-335X
- Abstract
- The rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Here, we present a methodology that can guide the recruitment of osteoblasts to bone defects with topographically defined implants (TIs) for efficient in vivo bone repair. We compared circular TIs that had microgrooves in parallel or radial arrangements with nonpatterned implants for osteoblast migration and in vivo bone formation. In vitro, the microgrooves in the TIs enhanced both the migration and proliferation of osteoblasts. Especially, the microgrooves with radial arrangement demonstrated a much higher efficiency of osteoblast recruitment to the implants than did the other types of implants, which may be due to the efficient guidance of cell migration toward the cell-free area of the implants. The expression of the intracellular signaling molecules responsible for the cell migration was also upregulated in osteoblasts on the microgrooved TIs. In vivo, the TI with radially defined topography demonstrated much greater bone repair in mouse calvarial defect models than in the other types of implants. Taken together, these results indicate that implants with physical guidance can enhance tissue repair by rapid cell recruitment.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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