Applications of Bioinspired Platforms for Enhancing Immunomodulatory Function of Mesenchymal Stromal Cellsopen access
- Authors
- Kim, Ok-Hyeon; Jeon, Tae Jin; So, Young In; Shin, Yong Kyoo; Lee, Hyun Jung
- Issue Date
- Aug-2023
- Publisher
- KOREAN SOC STEM CELL RESEARCH
- Keywords
- Mesenchymal stromal cells (MSCs); Immunomodulation; Biomechanical forces; Biophysical cues
- Citation
- INTERNATIONAL JOURNAL OF STEM CELLS, v.16, no.3, pp 251 - 259
- Pages
- 9
- Journal Title
- INTERNATIONAL JOURNAL OF STEM CELLS
- Volume
- 16
- Number
- 3
- Start Page
- 251
- End Page
- 259
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70039
- DOI
- 10.15283/ijsc22211
- ISSN
- 2005-3606
2005-5447
- Abstract
- Mesenchymal stromal cells (MSCs) have attracted scientific and medical interest due to their self-renewing properties, pluripotency, and paracrine function. However, one of the main limitations to the clinical application of MSCs is their loss of efficacy after transplantation in vivo. Various bioengineering technologies to provide stem cell niche-like conditions have the potential to overcome this limitation. Here, focusing on the stem cell niche microenvironment, studies to maximize the immunomodulatory potential of MSCs by controlling biomechanical stimuli, including shear stress, hydrostatic pressure, stretch, and biophysical cues, such as extracellular matrix mimetic substrates, are discussed. The application of biomechanical forces or biophysical cues to the stem cell microenvironment will be beneficial for enhancing the immunomodulatory function of MSCs during cultivation and overcoming the current limitations of MSC therapy.
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