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Identification of high affinity peptides for capturing norovirus capsid proteins
- Authors
- Hwang, H.J.; Ryu, M.Y.; Park, J.P.
- Issue Date
- 2015
- Publisher
- Royal Society of Chemistry
- Citation
- RSC Advances, v.5, no.68, pp 55300 - 55302
- Pages
- 3
- Journal Title
- RSC Advances
- Volume
- 5
- Number
- 68
- Start Page
- 55300
- End Page
- 55302
- ISSN
- 2046-2069
- Abstract
- Here, we present a platform where novel short and linear peptide motifs that enable binding to norovirus capsid proteins are selected by M13 phage display. The best peptide which recognizes recombinant norovirus 6H-P2 proteins has a sequence of 'QHIMHLPHINTL' and the apparent dissociation binding constants (Kd,app) of the selected peptides was found to be 185 nM of affinity. © The Royal Society of Chemistry.
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