Detailed Information
Cited 10 time in 
Cited 13 time in 
Cited 13 time in
Metadata Downloads
Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications
- Issue Date
- Apr-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Lipid polymer hybrid nanospheres; Antiproliferative drugs; Human aortic smooth muscle cells; Anti proliferation assessment; Cytotoxicity on human aortic endothelial cells
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.36, pp 284 - 292
- Pages
- 9
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 36
- Start Page
- 284
- End Page
- 292
- ISSN
- 1226-086X
1876-794X
- Abstract
- Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.