Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in octogenarian patients with non-valvular atrial fibrillationopen access
- Authors
- Kim, Hyue Mee; Choi, Eue-Keun; Park, Chan Soon; Cha, Myung-Jin; Lee, Seo-Young; Kwon, Joon-Myung; Oh, Seil
- Issue Date
- Mar-2019
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.14, no.3
- Journal Title
- PLOS ONE
- Volume
- 14
- Number
- 3
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70279
- DOI
- 10.1371/journal.pone.0211766
- ISSN
- 1932-6203
- Abstract
- Background and objective Elderly patients with atrial fibrillation (AF) are known to have a high risk of stroke and bleeding. We investigated the effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) in octogenarian patients with non-valvular AF compared with warfarin. Methods A total of 687 octogenarian patients with AF who were administered NOACs (n = 403) or warfarin (n = 284) for stroke prevention between 2012 and 2016 were included. Thromboembolic (TE) events (stroke or systemic embolism), major bleeding events, and all-cause death were analyzed. Results The NOACs group (age 83.4 +/- 3.2 years, women 52.4%, CHA(2)DS(2)-VASc score 5.0 +/- 1.8) comprised 141 dabigatran, 158 rivaroxaban, and 104 apixaban users. Most patients from the NOACs group had been prescribed a reduced dose of medication (85.6%). During 14 +/- D18 months of follow-up periods, there were 19 TE events and 18 major bleeding events. Patients with NOAC showed a lower risk of TE (1.84 vs. 2.71 per 100 person-years, hazard ration [HR] 0.134, 95% confidence interval [CI] 0.038-0.479, P = 0.002), major bleeding (1.48 vs. 2.72 per 100 person-years, HR 0.110, 95% CI 0.024-0.493, P = 0.001), and all-cause death (2.57 vs. 3.50 per 100 person-years, HR 0.298, 95% CI 0.108-0.824, P = 0.020). Conclusion In octogenarian Asian patients with AF, NOACs might be associated with lower risks of thromboembolic events, major bleeding, and all-cause death than warfarin. Although most patients had received reduced doses, on-label use of NOACs was effective and safe.
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