Low angiomotin-p130 with concomitant high Yes-associated protein 1 expression is associated with adverse prognosis of advanced gastric cancer
- Authors
- Hong, Soon Auck; Son, Myoung Won; Cho, Junhun; Jang, Si-hyong; Lee, Hyun Ju; Lee, Ji-Hye; Cho, Hyun Deuk; Oh, Mee-Hye; Lee, Moon Soo
- Issue Date
- Nov-2017
- Publisher
- WILEY
- Keywords
- Advanced gastric cancer; angiomotin; Yes-associated protein 1; immunohistochemistry
- Citation
- APMIS, v.125, no.11, pp 996 - 1006
- Pages
- 11
- Journal Title
- APMIS
- Volume
- 125
- Number
- 11
- Start Page
- 996
- End Page
- 1006
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70526
- DOI
- 10.1111/apm.12750
- ISSN
- 0903-4641
1600-0463
- Abstract
- Angiomotin (AMOT) promotes angiogenesis and plays a role in neovascularization during tumorigenesis. Recently, the AMOT isoform, AMOT-p130, was shown to exert a regulatory effect on Yes-associated protein 1 (YAP1), a major downstream effector of the Hippo pathway. The specific roles of AMOT-p130 and YAP1 in advanced gastric cancer (AGC) are yet to be established. In this study, a total of 166 patients with AGC were enrolled, and AMOT-p130 and YAP1 levels were analyzed by immunohistochemistry using tissue microarrays. Low AMOT-p130 together with high YAP1 expression (n = 30, 18.1%) was associated with high T stage (p = 0.042), high TNM stage (p = 0.025), and venous invasion (p = 0.048). A Kaplan-Meier survival analysis with log-rank test revealed a significant correlation with decreased AMOT-p130 coupled with high nuclear YAP1 expression with shorter overall survival (p = 0.0045) and disease-free survival (p = 0.0028). Furthermore, multivariate analyses showed that the low AMOT-p130/high YAP1 expression profile was an independent prognostic factor for disease-free survival (p = 0.008, HR = 1.874, CI, 1.177-2.986) and overall survival (p = 0.012, HR = 1.903, CI, 1.152-3.143). Our findings collectively demonstrate that low AMOT-p130 combined with high YAP1 expression is correlated with an unfavorable AGC prognosis.
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