Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment
- Authors
- Byun, Min Ji; Seo, Hee Seung; Lee, Joonghak; Ban, Kitae; Oh, Serim; Lee, Yun Young; Lim, Jaesung; Lee, Na Kyeong; Wang, Chi-Pin James; Kim, Minjeong; Han, Jun-Hyeok; Park, Juwon; Paik, Taejong; Park, Hee Ho; Park, Tae-Eun; Park, Wooram; Kim, Se-Na; Park, Dae-Hwan; Park, Chun Gwon
- Issue Date
- Apr-2024
- Publisher
- John Wiley and Sons Inc
- Keywords
- atopic dermatitis; immunosuppression; layered double hydroxides; macrophage polarization; nanohybrid
- Citation
- Small, v.20, no.17
- Journal Title
- Small
- Volume
- 20
- Number
- 17
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70703
- DOI
- 10.1002/smll.202304862
- ISSN
- 1613-6810
1613-6829
- Abstract
- Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments. © 2023 Wiley-VCH GmbH.
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