Topological implications of DNA tumor viral episomesopen access
- Authors
- Kim, Eui Tae; Kim, Kyoung-Dong
- Issue Date
- Dec-2022
- Publisher
- 생화학분자생물학회
- Keywords
- 3D genomics; DNA tumor viruses; Epigenetics; Viral episome; Viral latency
- Citation
- BMB Reports, v.55, no.12, pp 587 - 594
- Pages
- 8
- Journal Title
- BMB Reports
- Volume
- 55
- Number
- 12
- Start Page
- 587
- End Page
- 594
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70726
- DOI
- 10.5483/BMBRep.2022.55.12.154
- ISSN
- 1976-6696
1976-670X
- Abstract
- A persistent DNA tumor virus infection transforms normal cellsinto cancer cells by either integrating its genome into hostchromosomes or retaining it as an extrachromosomal entitycalled episome. Viruses have evolved mechanisms for attachingepisomes to infected host cell chromatin to efficiently segregatethe viral genome during mitosis. It has been reported that viralepisome can affect the gene expression of the host chromosomesthrough interactions between viral episomes and epigenetic regulatoryhost factors. This mini review summarizes our currentknowledge of the tethering sites of viral episomes, such asEBV, KSHV, and HBV, on host chromosomes analyzed bythree-dimensional genomic tools.
- Files in This Item
-
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70726)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.