High- sensitivity C- reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
- Authors
- Cho, Yuri; Park, So Youn; Lee, Jeong-Hoon; Lee, Dong Hyeon; Lee, Minjong; Yoo, Jeong-Ju; Choi, Won-Mook; Cho, Young Youn; Lee, Yun Bin; Yoon, Jae Woong; Kwon, Jung Hee; Cho, Eun Ju; Yu, Su Jong; Kim, Yoon Jun; Yoon, Jung-Hwan; Kim, Chung Yong; Lee, Hyo-Suk
- Issue Date
- May-2014
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- spontaneous bacterial peritonitis; C-reactive protein; liver cirrhosis
- Citation
- JOURNAL OF CLINICAL GASTROENTEROLOGY, v.48, no.5, pp 444 - 449
- Pages
- 6
- Journal Title
- JOURNAL OF CLINICAL GASTROENTEROLOGY
- Volume
- 48
- Number
- 5
- Start Page
- 444
- End Page
- 449
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70844
- DOI
- 10.1097/MCG.0b013e3182a6cdef
- ISSN
- 0192-0790
1539-2031
- Abstract
- Background/Aims:The production of high-sensitivity C-reactive protein (hs-CRP) may be affected by hepatic function, and the clinical importance of hs-CRP in patients with liver cirrhosis is still not clear. The aim of this study was to evaluate the clinical implications of hs-CRP in cirrhotic patients with spontaneous bacterial peritonitis (SBP).Methods:We retrospectively investigated 336 consecutive patients treated for SBP from 2007 to 2012. The relationship between serum hs-CRP and the result of the treatment was assessed.Results:A response to antibiotics was observed in 182 patients (54.2%), and 126 patients (37.5%) died of SBP. The initial hs-CRP (odds ratio=1.061, P=0.016), coexistent hepatocellular carcinoma, and Child-Pugh (CP) score were independent prognostic factors for high in-hospital mortality. Serum hs-CRP level was also an independent predictor of lower antibiotic response rate (odds ratio=0.916, P<0.001). However, hs-CRP was negatively correlated with the CP score (r=-0.199, P<0.001) and Model for End-Stage Liver Disease score (r=-0.182, P=0.001).Conclusions:This study found that serum hs-CRP level is related to a lower response rate to antibiotics, a higher mortality rate in patients with SBP. The hs-CRP level was negatively correlated with the CP and Model for End-Stage Liver Disease scores, which suggests that the prognostic function of hs-CRP was not a surrogate for hepatic dysfunction.
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