Allulose enhances epithelial barrier function by tight junction regulation via the TLR4/MyD88/NF-κB immune signaling pathway in an intestinal Caco-2 cell model
DC Field | Value | Language |
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dc.contributor.author | Baek, Jihye | - |
dc.contributor.author | Kim, Jong-Hwa | - |
dc.contributor.author | Nam, YoHan | - |
dc.contributor.author | Kim, Go-Eun | - |
dc.contributor.author | Ryu, Kyungheon | - |
dc.contributor.author | Sa, Soonok | - |
dc.contributor.author | Han, Jung-Sook | - |
dc.contributor.author | Kim, Wonyong | - |
dc.date.accessioned | 2024-01-11T08:00:21Z | - |
dc.date.available | 2024-01-11T08:00:21Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70951 | - |
dc.description.abstract | D-allulose, a fructose isomer with almost zero calories, has been widely used as a food ingredient that is generally recognized as safe. In recent studies, D-allulose has been shown to alleviate some diseases via restoration of the intestinal barrier. To better understand the role of D-allulose in intestinal epithelial barrier function, we conducted experiments to demonstrate its effects. Our results demonstrated that D-allulose increased transepithelial electrical resistance and decreased intestinal barrier function–associated permeability toward 4 kDa FITC–dextran flux in the damaged intestinal epithelial barrier. It also repaired the disruption pattern of tight junction proteins (ZO-1, occludin, and claudin-1) and inhibited the inflammatory response by inhibiting the TLR4/MyD88/NF-κB pathway. Overall, these findings suggest that D-allulose has the potential to be a beneficial food supplement for improving intestinal epithelial barrier dysfunction. © 2023 The Author(s) | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Allulose enhances epithelial barrier function by tight junction regulation via the TLR4/MyD88/NF-κB immune signaling pathway in an intestinal Caco-2 cell model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jff.2023.105721 | - |
dc.identifier.bibliographicCitation | Journal of Functional Foods, v.108 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001148634300001 | - |
dc.identifier.scopusid | 2-s2.0-85167794274 | - |
dc.citation.title | Journal of Functional Foods | - |
dc.citation.volume | 108 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | D-allulose | - |
dc.subject.keywordAuthor | Immune regulation | - |
dc.subject.keywordAuthor | Tight junction | - |
dc.subject.keywordAuthor | TLR4/MyD88/NF-κB signaling | - |
dc.subject.keywordPlus | RARE SUGAR | - |
dc.subject.keywordPlus | RECEPTOR 4 | - |
dc.subject.keywordPlus | D-PSICOSE | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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