Allulose enhances epithelial barrier function by tight junction regulation via the TLR4/MyD88/NF-κB immune signaling pathway in an intestinal Caco-2 cell modelopen access
- Authors
- Baek, Jihye; Kim, Jong-Hwa; Nam, YoHan; Kim, Go-Eun; Ryu, Kyungheon; Sa, Soonok; Han, Jung-Sook; Kim, Wonyong
- Issue Date
- Sep-2023
- Publisher
- Elsevier Ltd
- Keywords
- D-allulose; Immune regulation; Tight junction; TLR4/MyD88/NF-κB signaling
- Citation
- Journal of Functional Foods, v.108
- Journal Title
- Journal of Functional Foods
- Volume
- 108
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70951
- DOI
- 10.1016/j.jff.2023.105721
- ISSN
- 1756-4646
2214-9414
- Abstract
- D-allulose, a fructose isomer with almost zero calories, has been widely used as a food ingredient that is generally recognized as safe. In recent studies, D-allulose has been shown to alleviate some diseases via restoration of the intestinal barrier. To better understand the role of D-allulose in intestinal epithelial barrier function, we conducted experiments to demonstrate its effects. Our results demonstrated that D-allulose increased transepithelial electrical resistance and decreased intestinal barrier function–associated permeability toward 4 kDa FITC–dextran flux in the damaged intestinal epithelial barrier. It also repaired the disruption pattern of tight junction proteins (ZO-1, occludin, and claudin-1) and inhibited the inflammatory response by inhibiting the TLR4/MyD88/NF-κB pathway. Overall, these findings suggest that D-allulose has the potential to be a beneficial food supplement for improving intestinal epithelial barrier dysfunction. © 2023 The Author(s)
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